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NMH | 2024 73 Neonatal Encephalopathy Case No. EGA BW (g) Delivery Method Delivery Method Indication Apgars 1, 5, 10, 15, 20 PPV at 10 mins Min pH within 60 min Max BE within 60 min Seizures Y/N TH Grade of NE Summary of MRI brain Organ Involvement Outcome Placental Histology Classification 1 36+3 2965 Emer- gency C-Section Antepartun hae- morrhage, Fetal bradycardia 1, 4, 5 Yes 6.8 -27.8 Yes Yes 2 Abnormal: basal ganglia pattern of ischaemia/ infarction Venitilated Transferred to referring hospital on day 12 of life No placenta in NMH 1, 2, 3, 4 HIE outborn 2 37+0 3450 Emer- gency C-Section Reduced fetal movements, abnormal CTG, poorly controlled diabetes 1, 5, 7 Yes 6.88 -17.5 Yes Yes 3 Abnormal: global pattern of ischaemia/ infarction Ventilated, multi-organ dysfunction Died on day 4 of life, coro- ners post morten directed Small, maternal vas- cular malperfusion and delayed villlous maturation sec- ondary to maternal diabetes 2, 3, 4, HIE outborn 3 38+3 3700 Emer- gency C-Section Abnormal CTG, antepartum hae- morrhage 1, 1, 1 Yes 6.98 -24 Yes Yes 2 Abnormal: basal ganglia pattern of ischaemia/ infarction No Discharged home on day 18 of life Hypercoiled cord, FVM 1, 2, 3, 4 HIE outborn 4 38+6 2770 Emer- gency C-Section Meconium stained liquor, planned for C-section for previous myo- mectomy 5, 6, 8 Yes 7.18 -9.1 No Yes 2 Normal Ventilated, severe pulmonary hypertension, ECMO in Sweden Discharged home on day 33 of life No placenta in NMH 2 HIE outborn Hypoxic Ischaemic Encephalopathy: Outborn (12) Case No. EGA BW (g) Delivery Method Delivery Method Indication Apgars 1, 5, 10, 15, 20 PPV at 10 mins Min pH within 60 min Max BE within 60 min Seizures Y/N TH Grade of NE Summary of MRI brain Organ Involvement Outcome Placental Histology Classification 1 40+6 3740 Operative vaginal (ventouse) Abnormal CTG, ante- partum hae- morrhage 8, 8 No 7.24 -6.8 Yes Yes 2 Normal No Discharged home on day 7 of life Acute chorioamnion- itis, maternal vascu- lar malperfusion NE with sei- zures inborn, no HIE 2 41+2 4110 Operative vaginal (ventouse, forceps) Abnor- mal CTG, meconium, maternal pyrexia 5, 6, 7 No 7.16 -8 Yes Yes 2 Abnormal: small, uniilateral, focal areas of cerebellar, occipital lobe and corpus callosum ischaemia No Discharged home on day 5 of life Acute chorioamnion- itis, low grade villitis. NE with sei- zures inborn, no HIE Neonatal Encephalopathy: Inborn (2)