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47 Neonatal Encephalopa y NMH Annual Rep t | 2020 No. of Cases 2020 Inborns Outborns Neonatal Encephalopathy - with HIE • Mild HIE (Grade 1) • Moderate HIE (Grade 2) • Severe HIE (Grade 3) Neonatal Encephalopathy 8 0 4 4 0 4 0 2 2 2 Seizures – No Encephalopathy 4 0 Therapeutic Hypothermia 8 5 Infants undergoing Therapeutic Hypothermia in NMH 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 Inborn HIE cases reported 14 10 12 9 19 9 9 9 5 8 Number cooled 12 10 11 9 18 9 9 9 5 8 NE cases reported 13 19 7 4 2 5 2 4 0 0 Number cooled 0 7 3 0 2 2 2 4 0 0 Total 27 (12 cooled) 29 (17 cooled) 19 (14 cooled) 13 (9 cooled) 21 (20 cooled) 14 (11 cooled) 11 (11 cooled) 13 (13 cooled) 5 (5 cooled) 8 (8 cooled) Outborn HIE cases reported 5 8 8 13 8 6 10 2 6 4 Number cooled 5 7 7 12 8 5 9 2 6 4 NE cases reported 0 2 4 1 1 1 1 0 2 2 Number cooled 0 1 2 0 1 1 1 0 1 1 Total 5 (5 cooled) 10 (8 cooled) 12 (9 cooled) 14 (12 cooled) 9 (9 cooled) 7 (6 cooled) 11 (10 cooled) 2 (2 cooled) 8 (7 cooled) 6 (5 cooled) Total Inborn and Outborn Cases 32 39 31 27 30 21 22 15 13 14 Total receiving Therapeutic Hypothermia Inborn infants cooled 12 17 14 9 20 11 11 13 5 8 Outborn infants cooled 5 8 9 12 9 6~ 10 2 7 5 Total 17 25 23 21* 29^ 17~ 21~ 15 12∞ 13 * 2 other inborn infants were cooled in 2014 but are excluded from the above table as both of these infants were diagnosed with early onset neonatal sepsis. ^one outborn infant was cooled in 2015 but is excluded from the above table as the infant was diagnosed with a congenitally acquired condition postnatally. ~ one infant is not included in the hypothermia figures as although the infant was initially commended on cooling, it was discontinued as it was not tolerated. ∞One inborn infant was cooled in 2019 but is excluded from the above table as the infant was diagnosed with early onset neonatal sepsis. Please note as of 2017, infants who have seizures but who are not clinically encephalopathic are excluded from the above table.